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ruffies lid 

(sarcasm) Placing a napkin on top of a drink at a bar to indicate that you do not want a ruffie (Rohypnol) put in your drink while it's unattended.

Meant to be said in a sarcastic manner. Clearly this would not stop someone from putting something in your drink. Useful as a way to maintain awareness that you should always watch your drink without sounding like you are someone's mother.

Most often used to indicate to the bartender that the patron will be returning (so they don't throw your drink away) and/or that the seat is occupied. Typically done when a patron is using the bathroom or outside smoking a cigarette.
"I use a ruffies lid to make sure my drink doesn't get ruffied when I'm in the bathroom. This lets the sickos out there know that they shouldn't ruffie my drink, it has a lid protecting it."
ruffies lid by B-rad from Sound-Yo December 9, 2016

ruffie colada 

When you are having a drinking marathon, it is the drink that puts you over the edge.
That shot of rumplemintz must have been a ruffie colada, cause I don't remember anything after it. Ruffie colada--it will make you feel good, and steal a tiger!
ruffie colada by Jerry Bob Garcia February 19, 2011

Ruffie Hacker 

A Ruffie Hacker is someone who tries to make their own date rape drug with over the counter sleeping pills
Keith couldnt get laid so he became a Ruffie Hacker
Ruffie Hacker by Jseanwit December 23, 2011
the act of getting durbz or a blow job during the playing of the video game call of duty modern warfare 2 (cod)
ay yo indy im gettin ruffles right now..... right on spleen!
ruffles by low key beast December 23, 2009
Less common spelling of roofie, a tablet of the sedative flunitrazepam. Used for date rape.
She's had a roofie slipped in her drink.
ruffie by Spell September 30, 2004
Someone that listens to hardcore drum and bass, hardcore jungle, etc.
We are the ruffest
Ruffest by stanley88845 September 3, 2019