PYHO is an acronym like LOL, ROTFL or BRB.

PYHO stands for "Pull Your Head Out".
If you would PYHO you could get through your math finals and not have repeat High School!
by Lauribabe & Harley May 21, 2009
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A pyhoe is a team fortress 2 pyro main who only spams w and presses mouse 1.
Man that pyhoe is really annoying.
by u smelly February 3, 2021
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