Top Definition
Acronym for "I Miss You So Much It Hurts Sometimes". Reference to Scrubs s1e03:

JD's inner voice: Tell him how you feel without sounding like a girl for once.
JD (to Turk): I miss you so much it hurts sometimes.
Person 1: I gotta go.
Person 2: OK, bye.
Person 1: You don't sound very sad about it.
Person 2: I am. IMYSMIHS.
by Ranga37 April 19, 2010

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