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That could be either of the two biggest digits on your feet;
or when spelled thusly: Big T.O.E. refers to the Big Theory Of Everything, which by it self, is self explanatory.
1. OUCH!!!!!!! I crushed my big toe!
2. The Big Theory Of Everything is a complicated mess of facts, figures and things totalling the sum 42.
bigtoe by J. Michael Reiter April 29, 2005
Bigtops is a special kind of weed, provided exclusively by Dutch coffeeshop 'The Stepping out'. Bigtops is known by its cutting edge smell and its ability to blaze people out of their skulls. It is not recommendable to smoke 'the nice biggins' whilst not an extreme expert in puffing the magic dragon. Side-effects may vary from nausia to certain deaths.
That nice biggins really did the trick, i'm high as a m*therf*cker!

or

If you smoke bigtops, you'll die.

I'm so high right now (because of bigtops), nothing can hurt me.. BANG!
Weed that makes you crazy in the head. The color of Bigtops is only slightly green, but mostly white because of all the THC the biggins contains.
Smoke Bigtops, or die tryin'
bigtops by padddddo August 1, 2008

dos bigotes 

spanish for "two mustaches" but also a slang term for playing golf
Hey let's go down to the drving range for some dos bigotes.
dos bigotes by Hey Sixman May 7, 2005
Derived from the name 'Blackmore-Heal'; to have a large unlucky toe.
"Hey, did you hear about Adam not being able to get into the Army, it was because of his bigtoe."
bigtoe by bigtoe November 3, 2004
Someone who has an undeniably large big toe in comparison to the opposite toe, and other toes in the population of the world.
i) "Woah! Adam, you've got a fuckin' big toe. That's your new name: Bigtoe. Live with it."
bigtoe by Blenks November 2, 2004