zyrtec Share definition Flag Zyrtec is an allergy medicine, not anti-depressant, i hope this news doesnt bring back your depression, but look on the bright side of things, your noses must be very clear! Zyrtec makes my nose happy. zyrtec by Kiwikiki January 29, 2005 0 0 Get merch Get the zyrtec mug. Buy Now — $32.95 See more merch