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Mostly Irish expression for: "stop being an idiot" or "act more maturely"... literally: "act more wisely". Typically said in a scolding manner.
1. "god you look soooooo hot in that tight top..." "Hey you know I have a boyfriend, wise up."

2. "Stop acting like such a clown, it's a sophisticated party and they aren't impressed so wise up."
by Mr. Zed September 10, 2006
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