The five-knuckle-shuffle is another term for how a guy masturbates, Jerks off, gets his jollies, and says hello to his little friend.
Is it a sin to do the five-knuckle-shuffle in church?
by T. J. May 23, 2003
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The act of a girl giving a guy a hand job
Ethan: Yo you'll never guess what happened
Colin: What dude?
Ethan: Emma gave me the Five Knuckle Shuffle
by phillthethrill81 December 19, 2017
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"Mike you coming out with us". "Nah I'm to busy having a five knuckle shuffle to porn"
by Bigboidave June 11, 2015
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The guys above me are perverted dumbfuck sickos; Don't listen to them.

Five Knuckle Shuffle is one of WWE Smackdown! Superstar John Cena's signature moves. He does his "You Can't See Me" then runs to the ropes, bounces against them, brushes his soldier then jumps down and punches you right in the face.
Tazz: Ohhh there goes Cena with his "you can't see me!", Cole!

Cole: FIVE KNUCKLE SHUFFLE! And the pin...!
by Cena pwnz August 2, 2004
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The act of moving all five fingers on a single hand across another person's forearm, one at a time.
The gentleman greeted his friend home from vacation, with a lovely five knuckle shuffle.
by Bob Memphis December 13, 2009
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