S/E 

S/E: Save And Exit. A word meaning to Quit, Giveup, Your Garbage, You Suck, Noob.

My new acronym: S/E "Save And Exit"

Meaning, Quit, Giveup, Your Garbage.

Used in the gaming community.

S/E by Fogles September 8, 2008

s/e 

Easy Way For Cool Kid To Tell Save And Exit In The Game Diablo 2

Omg I own you noob , s/e plz

s/e by FrogZor July 11, 2006

S/E 

Term used to describe any consensual sexual encounter(s) between individuals of legal age. Primarily used by those in their 30's and above due to them being too DAMN old to say shit like "hook-up"(s)

I had to clean my bedroom because Nikki is coming over later tonight for a......S/E 🤫🤭

S/E by Professor Sequoia February 12, 2023

s/e 

Simply put, it means "Self-explanatory"

james56: wuts 'eat shit' mean?
markfark: its s/e

student: once u go 2 TurnItIn.com 'n enter the info, turning n ur paper is s/e

s/e by funkeywoookey March 24, 2008

S.E. 

Stands for Spontaneous Erection. When you're minding your own business and out of nowhere you get a boner and you're like FUCK!

I was sitting in math class when S.E. happened.

S.E. by frizzyoo March 14, 2010

s&e 

a title used to designate that girl who is both short and easy (s&e), and sleeps with every and any guy that she sees, is extremely disgusting and has the most annoying voice anyone could possibly here, should normally is seen wearing a bag over her head

hey, did you here what happened to john last night?
yeah, i heard that s&e cornered him, sucks!
yea, his eyes will stink for weeks

i heard that an s&e was on the loose...someone get her mask!

s&e by p.o.08 May 17, 2010

S.E. 

It's short for "Salty Euphoria"

Person: Whenever I have euphoria, it's usually S.E.

S.E. by SaltyS.E. June 15, 2017