pyzano Share definition Flag Those of Italian descent, usually very greasy and sleazy. Has a fondness for pizzas, clazones, and philly cheesesteaks. My uncle Vinny is one crazy pyzano; he loves him his pizza. pyzano by vinny dafunzalow April 13, 2007 0 0 Get merch Get the pyzano mug. Buy Now — $32.95 See more merch