I'm terrified of this girl. She's completely off the reservation.
by JtotheL March 1, 2006
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Going of the reservation is when certain elements such as spies or assassins either fail to complete an assignment/mission, go on an unauthorized mission, get caught and spill their guts, or go rogue. Usually resutlting in the need to neutralize(kill their ass) the said element.
lopez: hey man did you hear about that guy joe who worked with me at the CIA?
jimmy: no man what?
lopez: he went off the reservation and so I had to kill his stupid ass for going rogue.
jimmy: well thats what you get for trying to fucking double cross the CIA.
by mr. shakedown September 5, 2005
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A term sometimes used when a made man in the mafia kills another made man without the permission of his superiors.

A term sometimes used when agents in a spy agency, such as the CIA, go on unathorised assignments.
The Sopranos: "Tony B went off the reservation and wacked Billy Leotardo."

Spy Game: "If you go off the reservation, I will not come after you..."
by Fablo April 27, 2007
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a point in time when highly intoxicated or in another state of mind, may result in streaking and/or skinny dipping and blurred memories of the night before.
tonight im going off the reservation, please pick me up in the morning
by YouLikeThis-JMART April 30, 2011
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Highly offensive saying referring to American Indians that have left the reservation.
That crazy drunk, he's gone off the reservation.
by ClancyMan August 2, 2015
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When one or more members of a group (temporarily or permanently) splinter off to do something or behave in a way seen as unfavorable by their peers.
Miles: Wheres Doug at and what with all the commotion?

Fido: Yo, he's off the reservation, says hole 9 is rigged and is on a rampage, we gotta bounce before he drags us into this.

Miles: ... Yeah, that dumb ass is on his own, I ain't getting banned from Scandia cause he sucks at mini-golf.

Ashley: So there's a line for the bathroom so that drunk bitch is pooping in a trashcan.

Beth: Omfg shes so far off the reservation, I'm done her nasty ass, she can find new friends

Ashley: I know right, I don't think she even has anything to use for tp. Eww
by Maxdout June 12, 2021
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When a group disinvites your ass, grass and or cash for outrageous behavior, usually long past due.
Donald Trump was so boring at Studio 54 he should have been off the reservation.
by Not John Barron February 16, 2019
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