Being crazy, insane or stupid.
"Dude your completely off the handle"
by Da Boss03 February 7, 2018
To become angry or enraged.
"I'm Buddy Rich when I fly off the handle!"
by Socko August 10, 2004
Fly into a rage; lose control.
When a clumsy mother drops the roach I go off the handle on his ass.
by yarbuk February 23, 2012