The application of cologne to a man's body, generally by the man himself.
From the movie 'Anchorman: The Legend of Ron Burgundy' 2004

Brian Fantana: (about Veronica) I'll give this little cookie an hour before we're doing the no-pants dance. Time to musk up. (opens cologne cabinet)
by dmaenner August 11, 2006
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Worse than f*cked up, prone to happen when adding "tobacco" in your blunt or using drugs you're unfamiliar with.

Can also be to used to describe an epic f*ck up.
Bro you were so musked up at that party last night, wassup with that?

Yeah man crazy blunt did 360 all night long, then I musked up and ordered pizza for the whole campus.
by theway146 September 8, 2018
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to work up to
"i was just musking up the courage to do that"
by NOT christen December 14, 2003
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You messed up bad and let your venture capitalist fever dream ruin everyone’s day
Oh man, I Musked it up so bad last night. I bought a social media platform then ruined it for everyone
by SidTheSod July 1, 2023
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To completely mess something up and be 100% at fault for it. Though typically applied to business decisions it can apply to anytime someone messes up something really easy, also similar to making dumb statements the rest of the world knew was dumb but doubling down on it - similar to putting your foot in your mouth.
Bob thought NFTs would actually be an investment strategy after he saw it on the local news. he really musked it up.
by Nxano April 23, 2023
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