When a small male (including, but not limited to humans) has an issue with the rest of society because society tends to look down (literally and figuratively) on small people. Little Guy Syndrome (also: Little Man Syndrome) gives the "infected" person a aggressive attitude and thinks he some kind of "playground Muhammad Ali," and can beat everyone up.

NOTE: Not all small male humans, dogs, etc. have Little Guy Syndrome. And oddly enough, legitimate midgits tend not to have Little Guy Syndrome because they've already accepted the fact that they'll be forever short.
Example 1: The worst time a human male can have Little Guy Syndrome is when he's a point guard in basketball. Take Raquel for example. Raquel would have an amazing shot, but the fact that he's hardly five feet makes his shots get destroyed everytime he takes a contested shot. This makes him go berserk and act like he got fouled. Then when the ref tells him to calm down because he didn't get fouled, Raquel goes more insane and fouls everyone trying to steal the ball. He should /really/ see someone for his Little Guy Syndrome.

Example 2: I hate that damn woofy dog next door. It's got the worst Little Guy Syndrome. Everytime I step outside -even if it's only to take out the garbage- the thing goes nuts and tries to attack me until it's leash yanks it back.

by Carrera's Wedge May 30, 2007
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Someone that’s cute but you are unsure if you would date them. It’s a possibility though. Also used when thought to be in the friend zone to try and get out of it
Awww he’s such a cute little guy “
by 676869tit February 10, 2018
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Means to be exhausted or very tired; they can't handle staying up late
person1: I'm just gonna go to bed, I got up early today
person2: Aw what are you all little-guyed out?
by JennyD June 2, 2006
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A main character in the DGCU (danny gonzalez cinematic universe) always in the background of Danny Gonzalez’s videos.
wow cool a Little Nutcracker Guy in the background
by mryabyabyab June 21, 2022
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After I popped a little blue guy, I felt good as fuck! That’s when the real party began!
by Immunogoblin_A May 12, 2022
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A guy who behaves like a little bitch in so many situations, he can be generalized as "little bitch guy." Little bitch guy is not to be confused with "acts like a little bitch when he's with his girlfriend guy" because he's a little bitch regardless of his company.
A: "Dude I think I'm only going to do one set of pull ups today, I don't want to get a callus on my hands."

B: "Whatever you say little bitch guy"

A: (after friend jumps over fence to save some time getting to the bball courts) "Think I'll walk around man, that looks too hard and I don't want to hurt myself"
B: "Alright little bitch guy, I'll see you on the court."
by resevil787 February 18, 2013
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