hoheefa Share definition Flag form of "heffa" with a little "ho" to it. a fatty and a slut. not deragatory in all cases. What the hell are all these nasty hoheefas doing in here? What up hoheefa? hoheefa by newworldgurl December 27, 2006 0 0 Get merch Get the hoheefa mug. Buy Now — $32.95 See more merch