give up the ghost Share definition Flag Verb: to die in a submissive, peaceful fashion; or to die quickly, with finality, often brutally. The freight-train barreling towards him, his foot still stuck, no time, he decided to give up the ghost. give up the ghost by xmadmardiganx December 1, 2005 0 0 Get merch Get the give up the ghost mug. Buy Now — $32.95 See more merch