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sold down the river 

A phrase meaning to be betrayed by another. Originated during the slave trade in America. Selling a slave "down the river" would uproot the slave from their from spouses, children, parents, siblings and friends.
I can't believe that my manager said that project failure was my fault. I was really sold down the river on that one!

sending mandela down the river 

Taking a large dump and flushing the toilet a few times to get the entire contents down the pipe
"Where's Tony, we have a meeting in 2 minutes!" - "he's sending mandela down the river, he should be out in a minute"

Sell someone down the river 

To betray someone completely
Why would you try to sell someone down the river? That someone could accidentally be your grandmother.

Up The River Down The River 

Fill a solo cup with beer. Take a deck of 52 cards. Two people each draw a card. The person with the highest number (1 - 13) doesn't have to do anything. The person who draws the lowest card has to chug the beer for the amount of seconds equal to the difference in the cards. (example: Anna draws a four, Patty draws a nine). Anna has to chug beer for five seconds (use a stop watch). If you draw a joker, the person who drew the joker has to chug for three times the amount of the other card (example: Patty draws a joker, Anna draws a six. Patty has to chug for 18 seconds). The goal of the game is to finish the entire deck of 52 cards in the shortest amount of time. Can be played with multiple teams going against each other.
Hey Anna let's play Up The River Down The River tonight...

Okay Patty. It's on. Bring all your friends...

Going down the river Thames 

When you are having sexual intercourse and your partner has an urgent diarrhea, which he/she cant hold and lets go. But being the brave man that you are, you ignore the obstacle and keep on doing what you love the most... (no pun intended)
Bro, me and my sis totally went down the river Thames last night.
Going down the river Thames is my lifestyle.

floats the wrong way down the river 

a phrase referring to someone who is either gay or a lesbian.