Said in a kind way it means:

it's too bad, it's a pity

Said in an indifferent way it means:
it's tough, it doesn't matter, I could care less
Example of kind way:
Megan makes terrible hot chocolate, c'est dommage.

Example of indifferent way:
If you don't like my hot chocolate, c'est dommage.
by ray99 September 4, 2009
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an intentionally ironic statement meaning "What a Pity" or "What a Shame".
You hate being around smokers and your best friend goes in to a store to buy another pack but they are out of his brand; you can say: "Quel Dommage!"
by LanguageLoner May 28, 2010
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Used sarcastically when someone needs to suck it up. In french it means 'What a shame'.
Stan: And then I stubbed my toe on the copier!
John: Aww, quelle dommage, would you like some cheese with your whine?
by Fat Stanley March 14, 2011
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When you get utterly domed from a hit of nicotine. Like when you hit ur puff or Juul or nic device of choice and ur mind explodes.
Dude did u see Dennis? His cock fell off from the utter dommage.

Yea I know dude, he should get off that shit.
by Sackfest32 August 23, 2021
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