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Depo is an abbreviation of Depressed and can be used in many ways such as:
"That kid alex is sooo depo since he left school"
"I am a depo emo boy"
by gorga April 25, 2007
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Aug 11 Word of the Day
You can tell by the way she walks, she got that WAP.

You can look at her face and tell she ain't got that WAP.
by Black Don August 06, 2020
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2
Depo-Provera. A birth control solution given as a shot. Contains synthesized hormones similar to those in convential birth control pills. Administered as a shot every few months to prevent ovulation.
I asked my girlfriend to start getting depo shots because I didn't want her to get pregnant by my good for nothing sperm.
by sMOKEsTACK July 27, 2005
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3
1. Asshole
2. Dumbass
3. Blind to the world.
4. Someone your about to rip off
5. Best Buy slang for a needy customer
Someone who is blind to the world and a jerk at that. Jimmy is a flipping depo!
by Sketch Agui February 23, 2005
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4
Short for Home Depot. Depo is the highest insult to a person's intelligence that one can make, above Hardware store, Toolshed, Toolbox, and Tool.
Bob: Billy still uses Internet Explorer.

Joe: We've always thought he was a Depo, this is just the final nail in his coffin.
by CoonDawg1 November 03, 2008
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5
depressed; sad; untollerable
Aw, poor Mrs.Due, she seems depo!
by Carissa November 23, 2003
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