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You Only Senior Once - an expression used by both seniors in high school and seniors in college as an excuse to do something stupid or crazy. It's similar to "YOLO", but is reserved solely for the use of seniors.
"I didn't study for any of my finals, I was out partying all weekend. Whatever... YOSO!"
by aaayo October 29, 2015
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Jun 6 Word of the Day
True of COVID-19 sufferers and of George Floyd. The key phrase at this moment in American history.
"I can't breathe, said Floyd as he was being suffocated. "I can't breathe" thought more than 100,000 victims as they were dying of Covid. "I can't breathe" chanted countless Americans in the streets, protesting enduring police brutality.
by Monkey's Dad June 01, 2020
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3
You Only Stick Once. The process of hitting on multiple people knowing that you will at least hook up with one of them. The genesis of this acronym comes from the expression, "Throw enough shit against the wall and something is bound to stick."
I just tinder messaged 50 girls. At least one of them is going to be down. #yoso
by aro8888 August 20, 2014
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4
You only slide once. Termed for when you go on waterslides at waterparks and perform dangerous stunts and tricks on them. This usually occurs on rather large slides, with quite a bit of height.
"Jack is about to go down that giant waterslide while standing up!"
"YOSO, Jack! YOSO!"
by Brownie724 September 13, 2012
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5
You Only Sting Once

A famous saying for bees who have the urge to sting someone
Bee 1: Ugh, I'm pissed. I wanna sting a bitch.
Bee 2: Be careful. YOSO, you remember?
by MooMooMooMOOOO June 22, 2017
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6
The love child of "yo" and "so". Used to catch a peer's attention when one is about to say something important. Often capitalized when the shock factor of what the speaker is saying exceeds lowercase letters, becoming YOSO! When one is expressing concern or wary, they might draw the letters out to resemble "yooooossooooo". Derived from the popular comedy duo Jake and Amir. May also be used as a greeting between two friends.
Nicole: Yoso my cat threw up in the bong water.
Diana: Ugh, tits.

or

Amir: Yoso, when it snows my feet, they bleed coz my shoes have holes and I can nay afford socks'o.

or

Randall: YOSO PARTY AT MY PLACE TONIGHT!

or

Friend #1: Yoso
Friend#2: Yooosoooo I have a test tomorrow and I'm not ready!
by nicomeowmeow June 12, 2011
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