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To kill somebody or to arrange the murder of somebody.
Do you know who set up Vancouver Kingpin Sandip Duhre? Ya Robby Alkhalil did it, he got convicted for it.
Set up by AntiGang October 24, 2014
A person, place, or thing thats sole purpose is to start or create drama or misfortune towards certain individuals
Guy: "why haven't you text me or called me Im tryna get something going"
Girl: "No I know you gotta a girlfriend so me texting you would be a Set Up"
set up by AlleyWo July 9, 2009
a term used to define where a person lives
"hey baby girl, where's you set up?"
"H-Town"
set up by Lil MAC March 22, 2004
to square up or raise your fist to fight
dat nigga was poppin off so i set up and told him lets bang
set up by Spice2U June 18, 2007
v. The act of configuring or building an object, system, or process. Literally, "setting up" something.

Usually misspelled as "setup", which is the noun form of the thing that has been set up.
We set up the last of the servers this morning, so now the whole system setup is complete.
set up by Loadmaster August 25, 2005
Term used in regards to the introduction of a joke.
"Knock, knock. Who's there?" is a common set up.
"I really liked a bunch of Dave Attell's set ups. He's my favorite comedian.
Set up by Fuh Cup April 3, 2022