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In the 30th century, popplers were served for a while at the Fishy Joe restaurant chain after Captain Turanga Leela and her crew discovered tons of them lying in a hole on some unknown planet. Popplers taste delicious and look kind of like popcorn chicken. Warning: excessive consumption may prove hazardous to the continued existence of your species. (From the Futurama episode "The Problem With Popplers")
Pop a poppler in your mouth when you come come to Fishy Joe's/
What they're made of is a mystery, where they come from no-one knows/
You can pick 'em, you can lick 'em, you can chew 'em, you can stick 'em/
If you promise not to sue us you can shove one up your nose!
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1. A very delicious snack with unknown content from a mysterious planet.
2. A popular menu item for Fishy Joe's.
Pop a poppler in your mouth when you come to Fishy Joe's!

Leela isn't eating enough popplers.
popplers by MultipleSifl October 5, 2003

Princess Poppers 

A raging homosexual queen who loves to inhale amyl nitrate while having anal intercourse. Their first experience with poppers (which they think is cologne) gets them hooked and they just want to get all poppered up all the time!
"OH HELL NO, THERE IS JOSH!"
"Who? you mean Princess Poppers?"
"Yeah, look at that queen all poppered up on the dance floor acting a fool!"
Princess Poppers by NiggyPiggy January 16, 2009

let the poppers pop and the breakers break 

To be MC's, we got what it takes
Let the poppers pop and the breakers break
We're cool cool cats, it's like that

King of Rock
-Run D.M.C
Small canisters of nitrous oxide that are inhaled & gives several seconds of an Intense High, like you feel you're going a million miles an hour backwards!
Doing poppers is so much fun! What a blast & excellent high!
poppers by Starchylde May 28, 2016
Amyl nitrate and related volatile solvents, usually supplied in a small brown glass bottle. Name derives from the fact that the liquid used to come in glass ampoules for medicinal use as a cyanide antidote that 'popped' when broken open. Nowadays often supplied as 'room odorisers' or 'aromas' in order to get around medicines legislation, and used almost exclusively as a recreational drug and sex aid by gay men. Not actually illegal to possess in most countries. Works by relaxing smooth muscle thereby dilating blood vessels, causing a rush of blood to the head and drop in blood pressure, resulting in an intense but short-lived high. Also relaxes the muscle of the anal sphincter, thus facilitating the entry of foreign objects, especially large penises.
Russell took a deep inhalation of poppers just before Mark shoved his 10-inch cock into his arsehole, in order to ready it for the pounding it was about to receive.
poppers by ukfaggot April 24, 2006

Pimpin' Popples