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1.) A stain on clothing from McDonald's food.

2.) Any unusually greasy, hard-to-get-out stain.

3.) Generic term for an odious substance.

4.) A stain left on John McCain's tie after fornicating with the cattle lobby.

5.) Pejorative reference to John McCain
John McStain, that McStain upon the underwear of America, had a prominent McStain on his red tie.
by Stinkfinger May 27, 2008
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When you shart from eating too much McDonalds and leaves a stain in your britches.
I hate 10 Spicy McChickens and farted and it left a huge McStain in my underwear.
by carver605 April 24, 2016
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