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When you shart from eating too much McDonalds and leaves a stain in your britches.
I hate 10 Spicy McChickens and farted and it left a huge McStain in my underwear.
McStain by carver605 April 24, 2016
Related Words

Trent McSwain 

a type of person who will never get married
I had 5 dollars that he would get married, then I realized he was trent mcswain.
Trent McSwain by nobody27330 October 4, 2018
The act of hovering above a toilet while taking a mook to achieve ultimate domage while explosively cleansing your anus. The scarier the mook the better the McStand.

Other pronunciations: McStandy, Shitting-McStanding.
Zach: "How'd poop get on the wall!?"
Chuck: "I took a fat McStandy earlier. Almost fell off the toilet I got so domed."
McStand by Zelkins January 7, 2020

Mustainiac 

A devoted fan and maniac of Dave Mustaine, co-creator, the lead singer, main songwriter, and co-lead and rhythm guitarist of heavy/speed metal band Megadeth.
That Mustainiac moshing in the center is just fucking crazy!
Mustainiacs united to dominated the speed metal fandom!
Look at that Mustainiac licking Dave's hair!
Mustainiac by Larzs September 19, 2009

mustaine 

Used in the phrase "to pull a mustaine", to yell "FUCK YEAH!" in the most random and usually inappropriate of times.

Named for Dave Mustaine, vocalist/guitarist for Megadeth; derived from the song "The Mechanix", in which Mustaine for no reason yells "FUCK YEAH!" near the end.
"How could she tell Dave was watching the game and not listening to his girlfriend?"
"Well, she was talking about her sick cousin, but his team scored a goal and he just pulled a mustaine."
(verb): to engage in passionate kissing and groping; generally done in a club or bar. Usually involves aggressive tongue action.
Tom: Holy shit bro, I totally saw that asian girl and some dude McStine-ing last night on the dance floor.
McStine by H House January 18, 2012