Jim Carrey's exclamation of surprise and shock at the acquisition of new evidence, as seen in "Ace Ventura: Pet Detective". Can also denote happiness, digust, etc.
"Lois Einhorn? Missing hiker? Holy SHITBALLS!"
by Lolita & Herb March 16, 2007
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a young christian girl whos short. and well obviously has a face shaped like a ball. and enjoys customising shit and takeing rough concrete shits all over the placy
i clicked on a holy shitballs 's picture and then i clicked on another one. they were customized. the 2nd one had shit on her face
by truth of truths May 24, 2009
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N. An expression of surprise describing the process of getting piss drunk, then fucking a transvestite hooker, and waking up with shitballs in your ass. In conjunction with your hangover, you may find yourself either good surprised, or bad surprised, followed by the realization that holy shit your wife is going to be home in ten minutes/this bastard just fucked your wife/you're fucking gay.

Etymology - Derived from holy fuckballs, changed the word "fuck" from its verb/adjective case to a pure adjective to modify the word "shit", which, when added onto the term "balls" describes a penis that has recently gone through anal sex without a condom. Hence, "shitballs". Other variations include "shitdick" and "shitcock" and "shitwang" and finally, "shitpenis".
Holy Fucking Shitballs!

Who the fuck are you?
I'm gerry, remember me? We just had hot, sweaty, nasty anal sex.
Holy Fucking Shitballs
Hell yeah man, priest fucked me real good round about when I was ten.
by fuck you, the mighty fucker! October 15, 2010
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