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Capsaicin 

Capsaicin is a natural chemical found in spicy peppers. It is found in pepperoncini peppers, hot cherry peppers, jalapeño peppers, cayenne peppers, habanero peppers, ghost peppers, Carolina reapers, Pepper X, Plutonium hot sauce, and more. The hotter the pepper or chip or hot sauce, the more capsaicin it has and the higher the scoville level. Don't just jump right in to the spiciest peppers and hot sauces. Slowly build up your tolerance. Capsaicin is good for your heart.
I tried 5 hot cherry peppers. Hot cherry peppers have a scoville of about 2,500 to 5,000. That's not a lot of capsaicin. Red devil is delicious and has a scoville level of 800 to 1,200. Cayenne peppers have a scoville level of 30,000 to 50,000. Habanero peppers has a spice level of 100,000 to 350,000 scoville. Carolina reaper has a scoville level of 1,400,000 to 2,200,000 (about 1/8 the level of pure capsaicin). Pure capsaicin is 16,000,000 scoville.
Capsaicin by HawaiianPunch1 February 1, 2022
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capsaicin 

The chemical in chili peppers that makes them "hot." Actually a mild irritant.
"How many times more capsaicin does a habañero have than a jalapeño?"
capsaicin by Qit January 21, 2004

capsaicin 

CLuck-U Chicken's famous 911 sauce it made of pure capsaicin.
capsaicin by Iceet December 29, 2003

capsaicin 

JAMALIUS LAQUARIUS JANUARIUS THE 3RD: damn that is spicy
SOME NERD: Cus it has capsaicin you damn nigger. That's what makes it spicy yo.
capsaicin by ISOPROPYLALCOHOL December 5, 2023

capsaicin intolerance 

being a pussy. can't handle spice.
"I believe the correct terminology is capsaicin intolerance."
"So... you're a pussy?"
capsaicin intolerance by yagadooga December 23, 2020

Capsaicin intolerance 

Being a chicken and weak and a pussy. A pepper wimp! Can't handle not even a single drop of red devil hot sauce. Red devil hot sauce only has a scoville of 800-1,200. Can't handle not even eating 1 pepperoncini, which has merely 100-500 scoville. A kid could handle a pepperoncini.
Person 1: I can't handle a pepperoncini! Not even a slice of a pepperoncini. I have capsaicin intolerance.

Person 2: Don't be a pussy. Pepper wimp! *Drinks some red devil and eats a third of a hot cherry pepper.

*30 years later

*Person 1 has a kid with a wife.

Person 1's kid(who is called Stan and is 28 years old now): Look! I can eat hot cherry peppers and drink red devil and Tabasco! I even ate cayenne peppers!

Person 2: Holy crap!

*Person 2 and Stan has a hot cherry pepper eating contest and Stan won with 24 peppers and eats 2 and drinks a lot of water.

Stan: Ha! Who is the pepper wimp now? I avenged my father!

Person 1: That's my boy.

Person 2: Runs away in shame while drinking milk and eating yogurt and peanut butter to kill the spice.

Capsaicin Intolerant 

penguinz0: “I’m capsaicin intolerant”
CodeMiko: “So you’re a pussy”
Capsaicin Intolerant by AceKijani February 16, 2021
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