As in the drinking game, Buffalo. This is when both you and your friend are holding a alcoholic beverage and each must hold it in his non-dominant hand or else a "Buffalo!" may be called by pointing your elbow at them and yelling this word. Your friend must chug his drink.

Often played by frisbee players.
Grant will be hammered in 5 minutes; Leland just buffaloed him while he was holding a full Joose.
by shawty shorts November 17, 2009
Get the buffaloed mug.
1) (n) A large hairy mammal.
2) (n) A city in western New York.
3) (n, adj) A type of hot wing sauce.
4) (v) To intimidate, as by a display of confidence or authority.
Buffalo Buffalo buffalo buffalo buffalo Buffalo buffalo.
(it's a legitimate sentence, really...the 4th "buffalo" is the verb)
by Nick D December 4, 2005
Get the buffalo mug.
v. A synonym for vomit, typically used in the Orient. The word likely originated from the term yak, however, due to the ubiquity of yaks in some parts of south central Asia, the term buffalo is more appropriate and less confusing.
Anil: "Oh man, I feel gross! I think I'm gonna buffalo!!"
by YakLeatherPants April 15, 2011
Get the buffalo mug.
A wonderous *cough* city in Western New York, known mostly for chicken wings, our usually horrible football team, the insane amount of bars (that's mostly the Chip Strip and South Buffalo), and having spawned the Goos. Home of the #1 highschool and middle school in WNY - City Honors. If you're ever visiting during the summer, check out Thrusday at the Square.
Buffalo NY, hey - at least we're not Compton!
by Boochies August 27, 2003
Get the buffalo mug.
small city in western new york that is located next to lake erie. home of chad michael murray,teddy geiger, rick james, the goo goo dolls, and lucille ball. has two major sports teams: the good buffalo sabres and the terrible buffalo bills. the restaurant named the "anchor bar" is resposible for the chicken wing.
"let's go buffalo, lets go buffalo"
by clint bauer August 26, 2006
Get the buffalo mug.
A moderatly respectable blur collar town in western new york. Among other things, it is the final resting place of president Mckinley and former Hole bassist Kristen Pfaff.
by Anonymous August 1, 2003
Get the buffalo mug.
a slang term for marijuana originating from the Midwest, referring to the Native American custom to use every part of the buffalo.
"Save the stems of that buffalo, dude, we can use it later."

"Yo, dude, pick that nug up, you can't waste the buffalo."

"Dude, don't cash that buffalo yet, you can't waste the buff."
by chocolatemonster March 31, 2009
Get the buffalo mug.