Short for sister, commonly used as a term of endearment to friends in urban new york/jersey areas
by Caroline Might Fine November 14, 2016
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suck it everyday.

perfect for awkward silence moments; a reason for people to hate you for.
person 1: sup foo?
person 2: ....
person 1: huh?
person 2: well um...
person 1: sied nub

walks away
by One Six One February 6, 2008
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Not meaning “sister”. Commonly used to refer to a close friend or bestfriend.
what’s up, sis”
by kaitlyn pender January 24, 2019
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1) Short for sister
2) In the song Fuck the Pain Away by Peaches, SIS seems to stand for Stay In School...
My sis went to the movies with a scumball.

"Stay in school... Cause it's the best..."
by wxynot July 13, 2005
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Abbreviation for: "Sisters, In, Spirit". Your Best Friend or Bae. Usually used to refer to someone really close to you, someone you spend a lot of time with, like your sister.
Girl: OMG, squad on fleek!
Girl 2: yas, we look #Fabulous
Girl: Yas Sis Yas!
by ChocolateWafflez April 15, 2015
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