Definitions by ChocolateWafflez

SIS 

Abbreviation for: "Sisters, In, Spirit". Your Best Friend or Bae. Usually used to refer to someone really close to you, someone you spend a lot of time with, like your sister.

Girl: OMG, squad on fleek!
Girl 2: yas, we look #Fabulous
Girl: Yas Sis Yas!

SIS by ChocolateWafflez April 15, 2015