4:21 

the day after (mef know what i mean)

Stoner # 1 - duude yesterday....highest i've ever been.
Stoner # 2 - welcome to 4:21 mannnnn

4:21 by osama bin blazen February 7, 2008

4:21 

a minute afta 420

421 neva to late

4:21 by Tyz Gurl January 20, 2003

4:21 

a time for people that dont smoke to go and see the people that smoke and make fun of them

lets go to jakes house and see how high they are today

4:21 by brooke March 30, 2003

4:21 

4:21 from a professor

The time you try and pretend it is still 4:20 (professors can still smoke on 4:21)

4:21 by Pallet Wizard February 7, 2019

4/21

The day after National Marijuana Day. Also known for parents as National Drug Test day.

Billy: I'm going to smoke a shitload of pot on 4/20!

Bob: Your parents are psycho. I'm sure they are gonna make you piss in a cup on 4/21.

4/21 by Fuzzy Pinata April 20, 2010

4/21

4/20 = National weed day.
4/21 = National drug test day..

Tom: Hey Billy, 4/20 was lit bro
Billy: Not for me, my parents gave me a surprise drug test on 4/21

4/21 by Kezsailu Gang June 22, 2016

4/21

the day after national marijuana smoking day, the national pixie stick snorting day was established last year by Brandy and Emma.

shit bitchits 4/21, ima empty this pixie stick up my nose and snort it in the middle of the road while trying not to get my nigga ass run over.

4/21 by Emma and Brandy October 29, 2007