Down Syndrome 

A tragic mental illness some kids are born with. It makes them mentally retarded and physically deformed. It is in a word something neither the parents nor the damaged child should have to go through as it places an extra heavy burden on the parents and denies the child the chance he/she deserves at life.

My son was born with down syndrome. I still love him though

Paul Gowland got his ass kicked by that kid with down syndrome. He shouldnt be picking fights with a kid like that.

The world would be a better place without down syndrome

Down Syndrome by itsadamnshame March 22, 2010

Down Bad Syndrome 

When you feel bad and in pain and you affect all your other homies and now they're also down bad and in pain.

I have the Down Bad Syndrome bro. Gems was down bad and so was I.

Down Bad Syndrome by potatodarklord November 4, 2020

Down in the Trumps 

The act of misplacing one's own inadequacies on an external event which they had no control over. Feelings such as laziness, apathy, and lethargy because their parents told them "they can do anything" and they are now on their 5th year anniversary working as a barista which have made them depressed. They can externalize their problems by blaming Donald Trump as their President as the root for all of their problems.

I'm feeling down in the Trumps because I make $12 / hour and have $100k in student loans for my liberal arts degree.

Down in the Trumps by logic bunny April 24, 2017

Down-south

Used as a stereotypical insult Bashing the Following states: South Carolina, Georgia, Alabama, Mississippi, New Orleans or Texas implicating the insultee is from 1 of said states.

Calling someone "Down South" is saying they live up to most if not all the southern stereotypes:
1.) Poor Dental Hygiene
2.) Does sexual things to/with own family members
3.) Mentally Challenged

4.) Ignorant people who hate homosexuals and people of other races who aren't of the same race.
5.) Use Ther' instead of there.

6.) Republicans.

Guy 1: See what happen when u allow niggers into that there white house? Letting the middle east and Asia walk over us, giving lazy assess food stamps, making me pay more in taxes cuz I make money. The first n last nigger president I bet cha.

Guy 2: You Down-South ass nigga get over yoself!

Down-south by Danny Mattherson January 31, 2014

Down the shore Male Syndrome (DTSMS)  

A highly contagious mental disease caused by hanging around males down the shore with said illness. It's amongst the easiest to diagnose for what seems to look like full grown boys will act like 5 year-olds when encountering something that they do not understand. Such things include but are not limited to; emotion, intelligence or anything to do with people who have a higher chance of success in life. Said syndrome has only one speculated cure, and it is not yet known, however growing up is highly recommended as treatment for alleviation of symptoms. The syndrome is speculated to also be genetically inherited, and seriousness increased in those harbinger the Y chromosome

high school boys in the back of that bus clearly have "Down the shore Male Syndrome (DTSMS) " they hate on girls that like a guy that they don't know.

Down the shore Male Syndrome (DTSMS) by Kagomes_S January 15, 2009

down and brown 

To take part in the act of scat sex. A street way of saying that you or your partner defecated on the other during sex.

james got down and brown with that munter lastnight, she gave him his 20 quid's worth.

down and brown by Heskif April 21, 2007

down syndrome 

Another name for your Nintendo DS is Down Syndrome.

Brian: Hey dude do you have your Down Syndrome today?
Kevin: Yea i have my Down Syndrome and i brought golden eye for multi player.
Brian: Sweet.
Kyle: What the hell is a Down Syndrome?
Brian: Jesus Christ Kyle it's a DS.
Kyle: Oh
Audie: Shut up hoe!

down syndrome by Sir Co-Captain Grant Raymoure aka KJ June 14, 2007