Upside Down Syndrome

The disorder in which a person's Down syndrome is so severe that his face is completely rotated out of proportion. More severe cases can affect muscle girth, especially in the forearms. This renders the victim's forearms indistingiushable from pencils. One's speech may also become unamusing and trite.

Chris Max, what's up with your face?
Max BABABABAABaabaaba!!!
Chris O, you must have Upside Down Syndrome, which renders yours forearms indistingiushable from pencils and your speech unwitty. My bad.

by R. Areaux February 16, 2009

Big Fish Syndrome

A terminal disease that causes an individual to die of heart failure due to his/her enormous height.

David is pretty fucking tall and he's going to die soon," said Jeff, the coolest kid around.

by Superflylemonaid February 22, 2005

Empty Net Syndrome

When your friends that are normally online to help you chat your way through your work day decide to go on vacation or get jobs where they can't be online anymore. Similar to empty nest, you feel very alone!

Chrisy: I'm going to New York for the week.
Kim: Oh i got a new job. I start today, so I wont be online anymore during work hours.
Jen: Screw you guys, I'm going to have a serious case of Empty Net Syndrome. :-(

by jenbertoni March 19, 2009

James Bond Syndrome

Where people start talking with a fake british accent after watching 007

Person 1: "Cor blimey. This is a nice bloody surprise. What's this about, then?"

Person 2: "Dude, what's wrong with him?"
Person 3: "He just got a James Bond syndrome."

by Total Anon March 4, 2011

Trump Derangement Syndrome

Typically refers to someone who rejects the words or actions of President Donald Trump in a way that makes the person look foolish. TDS can afflict a person regardless of if his or her complaints are legitimate. TDS victims can often be found on social media sites, particularly Twitter and Facebook.
Contrast with Trump Enslavement Syndrome, which involves supporting Trump.

A: The President really messed up his response to the outbreak.
B: I know! He's killed thousands of people! I hope he dies!
A: Whoa, cool it with the Trump Derangement Syndrome.

by Ockerjj November 4, 2020

Trump Derangement Syndrome

A complete unhealthy obsession with Donald Trump believing he is the root of all evil. Think of it like the "Thanks Obama" meme but when people said this jokingly Trump Derangement Syndrome is serious. It has gotten to a point where Obama has actually spoken out about the lefts trump obsession.

Gee, this definition thread has the same few people making multiple definitions of this condition. I diagnose thee with Trump Derangement Syndrome.

by SchizoHAMR October 24, 2022

Polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects approximately 5% of all women. It occurs amongst all races and nationalities, is the most common hormonal disorder among women of reproductive age, and is a leading cause of infertility.

The principal features are weight problems, lack of regular ovulation and/or menstruation, and excessive amounts or effects of androgenic (masculinizing) hormones. The symptoms and severity of the syndrome vary greatly among women. While the causes are unknown, insulin resistance, diabetes, and obesity are all strongly correlated with PCOS.

girl: "I've been diagnosed for Polycystic ovary syndrome..."
guy: "ROFL, that's like the worst disease ever! You're going to be a fat, acne-prone, balding, bearded, infertile, depressed, wo-MAN!!!"
girl: "nonono that can't be right, maybe he misdiagnosed?"
guy: "Well you know, that's one awfully manly chin you've got there now that I think of it"
girl: " :O "
*(girl has gone offline)*

by UnlikablePrick April 23, 2009