DUFF

The glue to a friendship. She/he will always support there friends no matter what. She can be a pain in the ass but everyone still loves her/him.
wow she is such a duff, i love her.
by ofiherjonfoqe[h November 05, 2018
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duff

(D)esginated (U)gly (F)at (F)riend
You are a duff
We have a duff in our friend group
by huoon October 15, 2021
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Duff

by gamerpeeps500 August 23, 2021
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Duff

That place on the human body (particularly the female body) where the body makes contact when sitting-down, i.e. the erogenous area of the butt.
I'll bet her duff is as sweet as candy!
by March 03, 2023
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Duff

The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.
Jeff: Hey, let me get a ball of that fire ice. Dan: All I have left is the duff, bro.
by jlthomas110880 November 25, 2020
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