A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.
Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.
by NinjaSlayer_936 January 02, 2021
by IXYMIA May 14, 2025
A person who has many or all of the characteristics of a human being with down syndrome, yet they are not diagnosed with the disease.
by alkfjdklaf;adfakjd September 25, 2008
group of 4 teenage girls, (preppy brats), who take a small squirtgun game way to seriously. Must seriously be taken down. DOWN WITH THE QUAD!! :p
The quad is made of Kristie, Alexis, Liz, and Lindsay. Down with the Quad. Those girls need to chill the fuck out.
by DownWithTheQuad May 22, 2012
by Num nums🥰💯🦖 January 19, 2023
by TapCat February 10, 2021
by DJ DOWNSYNDROME November 20, 2017