A disease caught by picking up too many cards in UNO when playing by the rule "Pick up until you can put down" when needing a card.
Michael:"I Change colour to Blue"
Nick: "Darn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
John: "Oh damn."
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Nick: (picks up card)
Ash: Bro he's got Pick-up-till-put-down Syndrome!
Nick: (picks up card)
Nick: Finall-wait nevermind.
by NinjaSlayer_936 January 02, 2021
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took down

twin ahh went to Clayton county and got took down
by IXYMIA May 14, 2025
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master down

A person who has many or all of the characteristics of a human being with down syndrome, yet they are not diagnosed with the disease.
did you see chase's face today? he looked like a master down!
by alkfjdklaf;adfakjd September 25, 2008
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Down with the Quad

group of 4 teenage girls, (preppy brats), who take a small squirtgun game way to seriously. Must seriously be taken down. DOWN WITH THE QUAD!! :p
The quad is made of Kristie, Alexis, Liz, and Lindsay. Down with the Quad. Those girls need to chill the fuck out.
by DownWithTheQuad May 22, 2012
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down to fruitloop

Down to give head, eat pussy, and code word for a sexual act a male can do to a female
Are you down to fruitloop when everyone goes to sleep?
by Num nums🥰💯🦖 January 19, 2023
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PUT THE CONE DOWN!!!

Hey, I'm getting piz- PUT THE CONE DOWN!!!
by TapCat February 10, 2021
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dj down syndrome

My name is DJ down syndrome but you can call me Jef
by DJ DOWNSYNDROME November 20, 2017
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