This term origins from when mr. gunio once made an entire class driven to suicide. It is when an even takes place and repeats itself many times over and over, and you slowly become even more miserable, depressed and lose the tiny bit of happiness you ever had. you will even forget your best friend. for example, you study multiple hours for a week to prepare for a math test, and then he gives you a test on a completely different subject. or one person cheats on a test, and everybody gets an F because of that. Or, your math teacher tells your parrents you are misbehaving, when in reality, you only asked soemebody for a pencil one time.
me: my teacher told my parents i was bullying a kid for a pencil, but i was only asking him kindly to borrow his pencil.
friend: the gunio effect kicks in once again
friend: the gunio effect kicks in once again
by gabriel.exe February 18, 2017

Being extremely horny, especially around close friends of the same gender.
Usually happens over a wide time frame.
Highly contagious.
Usually happens over a wide time frame.
Highly contagious.
by The Aspect of the Soup December 11, 2022

A situation in which a seemingly normal or routine event either works in an unexpected way or not at all. Rarely reproducible, the phenomenon is as fleeting as it is confusing.
by Ed's Coworker April 1, 2007

"Tim are you okay?"
"No, I've had the trots this morning after last night's pizza"
"Oh, that's the Domino's Effect"
"No, I've had the trots this morning after last night's pizza"
"Oh, that's the Domino's Effect"
by K-Dogg 81 July 18, 2018

It means having too much traffic on a web site due to its link being posted on lifehacker.com as a feature article, sometimes even causing the featured web site to go down.
by mish1234568 March 14, 2009

Dave: Dude, I heard they were making a sequel to Boondock Saints.
Steve: I hope they don't apply the Disney effect to it.
Steve: I hope they don't apply the Disney effect to it.
by Ryanson April 27, 2007

The horrible cycle of a song getting stuck in your head because one ******* thinks its ok to play it 24/7.
by jo_cro April 19, 2010
