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I don't give a fuck 

Lack of giving fucks for a given, usually unpleasant scenario, but he who utters "I don't give a fuck" isn't phased by said scenario. However, in most cases , those who utter, especially yell "I DON'T GIVE A FUCK" usually do.
Guy 1: Hey dude sorry looks like Patriot lost the game tonight
Patriot Fan: I don't give a fuck

I don't give two shits 

Way of saying, I really could care less for this shit, and shut the fuck up. Wrapped up in one little phrase.
Dude #1: Hey, can you go water my plants while I'm gone?

Dude #2: I don't give two shits about your damn plants!

I don't give a holy fuck 

Another way of saying "I don't give a fuck", but with a little religion. People say this when other people say things to 'brag" or are annoying you by provoking you. This term will shut their asses down. Even if it doesn't, the other person will still back off for a little bit. Sometimes they will bite back at you saying you're jealous. At this point, you should tell them to suck a dick and fuck off in a garbage can. This also makes the other person more catholic.
Little Kid on Roblox: I got so much robux lol
Me: I don't give a holy fuck
Little Kid on Roblox: You jealous.
Me: Fuck off to a dumpster youngster

Little Kid on Roblox: I believe in god.

I don't give a what 

Polite way of saying "I don't give a fuck" by gangsters...

Ghetto talk.
O.G slaps a ghetto ass hoe

Young nigga: "dawg that ain't right..."

O.G: "I don't give a what!"
I don't give a what by *PIMP-R* March 17, 2011

I don't give a fuck 

Student to tha teacha: "I don't give a fuck 'bout what ya sayin', I don't give a fuck 'bout what ya doin', and I couldn't care less of you."
I don't give a fuck by KD Squib September 19, 2005

I Don't Give a Care 

Bill: I'm gonna snog your mom.
Jeff: I don't give a care.