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I users term to describe the horrible drug Cocaine.

Shortened versions(IE. Yay, Yo) are also the same thing.

Tip: Stay away from this drug
Hey bro, I just got 20 bucks, lets go get some Yayo
Yayo by User wanting to quit April 28, 2006
The word meaning 'Mother' in Swahili.
I'm going back home in 2 weeks to visit my yayo.
yayo by lilshizzy July 19, 2004
A Big Girl. Came from the rapper of G-unit Tony yayo because he likes big girls. From the song "Fat Chicks" by G-unit.
yayo by Sierra March 1, 2005
A man who likes, or fornicates with obeise women.
Yayo like's fat bitches
yayo by Willis Reed April 22, 2006
A fat girl. Comes from Tony Yayo from G-unit because he likes Fat girls. In the song "Fat Chicks" by G-unit
Oh you see that girl over there She is a Yayo.
yayo by Sierra May 13, 2005
a word thats supposed to be spelled llelo but looks cooler spelled as yayo. im not exactly sure of the origin, but it was made popular in scarface. tony yayo gives credit to that too if you listened to 8 mile remix by g-unit
tony: chichi, chichi! get the yayo

omar: you still got the money? tony: yeah, and i got llelo

corrupt cop: so tony, the word on the streets is your bringing in a lot of llelo, that means your not a small timer anymore
yayo by goul December 28, 2005