Mami Uno Share definition Flag Spanish phrase that means "THE FIRST LADY", also the name of a Chilean R&B singer from Toronto. DAMN, That track "I promise" by Mami Uno is on fire.You're right homie she really the MAMI UNO of Canadian hip hop. Mami Uno by pinkeeeee January 3, 2011 0 0 Get merch Get the Mami Uno mug. Buy Now — $32.95 See more merch