An exceptionally large number of people in a certain vicinity (party) of one another who have had sex with one another. Each person around can be connected through some sort of sexual act with another, very little degree of separation.
"Holy, shit. Do you know how many people at this party has slept with Tina? And then those guys over there slept with that one dude's girlfriend.
This is such a cluster fuck."
In the game of pool/billiards when a significant number of the balls are clustered closely together so as to limit the availability of open shots on the table.
A term used in sailing races when a lot of boats reach the buoy at the same time. Lots of yelling and swearing is involved, usually directed at the captains of other boats, or at your own boat's crew. High risk of collision. Often followed with excessive drinking.
"Whew, glad to be out of that cluster fuck, pop open a beerfor me, will ya?"