Up syndrome

When someone is so retarded they have "up syndrome" instead of down syndrome

yo mama so stupid she has up syndrome

by A_Walking_Meme June 18, 2019

Up Syndrome

When someone tends to hover above chimneys

Dolly has up syndrome, look at her hovering

by Dick Massive June 30, 2021

Pumped Up Kicks Syndrome

Dank ass music. Dark ass lyrics.

“Pumped Up Kicks” by Foster The People sounds like an upbeat song, but upon further examination, it is about a school shooting. Any song that has a happy tune, but dark lyrics has Pumped Up Kicks Syndrome.

by SB757 December 23, 2023

up syndrome

when you have so much down syndorme it inverts itself

"jozlen sussy jol" up syndrome

by jolzen December 1, 2022

Up Syndrome

When you get filthy rich in the trenches and retire your parents

cupsey got up syndrome

by probably trenching March 4, 2025

Q Up Syndrome

A term used for League of Legends players when they say "queue up," or play another game, when the player(s) is not mentally, emotionally, and/or financially stable. This act promotes both sadistic and masochistic characteristics to themselves that they are aware but ignorant of because LP addiction is more powerful than society. This condition is chronic and could lead to brain damage.

"I can't take it anymore... I'm going to Q up... ARUGHHHHH," Yerpyyy said.
"Yeah you have stage 4 and Q up syndrome," Mars replied.

by Yerpyyy July 14, 2023

Up syndrome

you say it to insult someone

you don't have down syndrome you have Up syndrome

by MangoMane January 25, 2025