S2S

Skin to skin. A loose term for the act of having sex with someone without contraceptives. So S2S is a sleek way of saying the same thing abbreviated.

I want us to go S2S during Netflix and Chill.

by Mbuba April 21, 2023

Friends SMP S2

Survival Multiplayer Server in the hit game Minecraft, with people that are pretty cool.

"Friends SMP S2 is Awesome"

by LeCate October 28, 2022

S2S

Sister 2 Sister

"sis, I got you...S2S forever".

"Unbreakable bonds"

by LadyJLauren August 26, 2021

S2 Gaming

Probably one of the worst mobile gaming teams that have existed.

S2 Gaming is pretty bad

by The Empire who is cool January 9, 2021