In the connotation of smoking tobacco/weed, to "go astro" means to smoke too much and to become too high to recognize your surroundings, like you were in the stars.
Newbie: *hits vapehard*
Good Friend: Ay be careful, don't go astro, man.
A blue fox with cybernetic powers and a good sense of justice and good, he does good because it's good, he won't be rude at all! He's a good boi, and a good furried friend to all animals :3
Dude #1 : It's so lonely around here...
Dude #2 : Maybe we should call Astro?
Dude #1 : Heck yeah! He's the life of the party!