When something goes horribly, horribly wrong, this phrase is directed at the aggressor. It can be used either before or after the person/object you're venting at, but not both. Additionally, it can never be used with "you" i. e. one could not say "Get out of my way, you prick of misery."
Person 1: Prick of Misery! The 2 train is running local from the Bronx all the way to Brooklyn. (In this case, the aggressor would be the MTA)
Or
Person 1: You hit me with your car! Prick of misery! (The driver is the aggressor)
Or
Person 1: You hit me with your car! Prick of misery! (The driver is the aggressor)
by CNJGeep May 26, 2009
Get the Prick Of Miserymug. A term, double word reference used to describe guys who have girlfriends, or guys who can get girlfriends, or guys who are, in general, pricks.
by Kingklin October 20, 2008
Get the Confident prickmug. veronica: I'm gonna break up with Rob. But first, I'm gonna show everyone this pic of his pinky prick!
by Bluvelvet72 July 27, 2018
Get the pinky prickmug. very large, too big for the face even, out of style sunglasses worn in an ironic way to look youthful and cool, i.e lindsay lohan, kanye west, paris hilton and fuggie fug.
by weezy74 March 28, 2007
Get the prick shadesmug. Someone who lords it over others in their social group, usually in the workplace, much as you get one fish in the tank who thinks it's better than the others
shit man, Tom is SUCH a prick fish, who does he think he is, always bowlin around like he owns the place
by D@v3 October 26, 2008
Get the Prick fishmug. 
by stephen shaw August 3, 2007
Get the prick weedmug.