UPI

Universal Prostate Institute.

A made-up institution to serve as an excuse when somebody asks where you graduated.

George: Do you have a degree in computer science?

Johnson: Oh yeah, I graduated at UPI...

by Bin_NoGoutHavinAss_Chang January 12, 2022

Sticky upie

Sticking up in all directions...such as hair when you wake up.

My hair is all sticky upie.

by Peaches9112 June 18, 2017

UPI

Unidentified party injury

dude...where'd you get that huge bruise. I don't recall. It's a upi from Saturday night.

by rawr kitty December 30, 2016

Upie

A word for littles in ddlb/ddlg/mdlg/mdlb to be picked up

"Upie!"

by An non no mass (Anonymous) May 5, 2019

Upis

To shoot a gun at a minor that doesn't know spanish and has two feet with 6 six toes

Oh look an Upis I need to shoot it

by Upis February 4, 2023