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I don't give a shit 

I don't give a shit is a popular phrase to be used when you are not interested in what someone else says or believes. It implies that you don't even care enough to physically give them a sample of your fecal matter.
Gamer 1#: Dude your computer sucks, you shell out $2000 for a kicass rig, and still run it on a piece of shit CRT monitor.

Gamer 2#:Well that may be but honestly, I don't give a shit.
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i don't give a fuck about shit

A medley of not giving a fuck and not giving a shit. In addition to expressing you don't give a fuck, you furthermore reduce the topics about which you don't give a fuck to shit.
I was thinking about her but then realized I don't give a fuck about shit

i don't give a single fuck 

A: Your ex-girlfriend slept with another guy in Class.
B: I don't give a single fuck! (well, you actually do)

I don't give two fucks 

Used to put more emphasis that you don't care.
Dan: you know mom will be mad if we're late for dinner but I don't give a fuck
Tom: Well, I don't give two fucks, she makes crappy meatloaf anyway

I don't give a damn

A: He likes you!
B: So what? I don't give a damn, he sucks.
I don't give a damn by One-republic February 28, 2009

I don't give a SHIT!!! SHIT!!! SHIT!!! 

When you really do not care about anything at all.

Coined by the Tourettes Guy.
Dad, you're not allowed to go back in there.

TG: I don't give a SHIT!!! SHIT!!! SHIT!!!

I don't give a ruff 

Expression to show your lack of concern on a subject,
oppposite of giving a ruff.
James "Yo, you that girl you did was a horse"
Rick " I don't give a ruff"