Up-syndrome

A person who is seriously ugly to the point no one wants to look at them without protective goggles.

That guy has up-syndrome, he’s such an uppy

by Lickle bump February 26, 2022

Up syndrome

When someone looks like they have down syndrome but they actually don't

Or do they

he looks up

he look he has up syndrome

by v842 November 18, 2022

Up Syndrome

Up Syndrome is when someone with Down Syndrome is high off weed

“Bro is he ok”
“Nah he’s having a bit of Up Syndrome”

by Wild Warren December 13, 2020

up syndrome

when you have so much down syndorme it inverts itself

"jozlen sussy jol" up syndrome

by jolzen December 02, 2022

Up syndrome

When someone is so retarded they have "up syndrome" instead of down syndrome

yo mama so stupid she has up syndrome

by A_Walking_Meme June 18, 2019

Up syndrome

you say it to insult someone

you don't have down syndrome you have Up syndrome

by MangoMane January 25, 2025

Glew up

past tense version of glow up 😤 -- made my puneet

I swear the mfs who I barely know glew up

by yjryj September 10, 2022