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Down the shore Male Syndrome (DTSMS)  

A highly contagious mental disease caused by hanging around males down the shore with said illness. It's amongst the easiest to diagnose for what seems to look like full grown boys will act like 5 year-olds when encountering something that they do not understand. Such things include but are not limited to; emotion, intelligence or anything to do with people who have a higher chance of success in life. Said syndrome has only one speculated cure, and it is not yet known, however growing up is highly recommended as treatment for alleviation of symptoms. The syndrome is speculated to also be genetically inherited, and seriousness increased in those harbinger the Y chromosome
high school boys in the back of that bus clearly have "Down the shore Male Syndrome (DTSMS) " they hate on girls that like a guy that they don't know.
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downsyndrome 

Genetic condition caused by a triple chromosome also known as chromosome 21. People with this condition are blessed with the gift of eternal innocence. They are usually harmless and friendly and incapable of violence. We like to think they need help but maybe it's really us who do.
"George Bush is a perfectly sain individual, no history of downsyndrom there, he can wage war all he wants"
downsyndrome by Flo January 29, 2004

Downsyndrome 

An extremely intelligent person who doesn't deserve hatred. Please keep the negative comments about Down syndrome people to yourself. Thank you
My little brother has {Downsyndrome} and is very intelligent and adorable!
Downsyndrome by alay.s May 5, 2016

Debbie Downsyndrome 

A person who is always down and it a bad mood, and puts others in bad moods as well. Usually is in a bad mood from being ugly or gettin made fun of.
person 1: "Tough fish"
person 2: "Heis, stop being Debbie Downsyndrome for 5 min"

Double Downsyndrome 

When two adults with down syndrome have a kid who also has down syndrome. Jokingly the kid would have twice as many extra chromosomes.
Double DownSyndrome
Doctor: No, you two shouldn't try for kids!
Dad: Kids? Kids!!
Kid: Nnyaa!