Ruin a chance completely. Did something very regrettable. Possible consequences: intense self-hate, suicide, depression etc.
'You cheated on your boyfriend for the sixth time?'
'Yeah, it was his best friend actually.'
'You fucked up big time!'
by dphn00 January 1, 2012
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A Big Fucking Cock
John put his Big Fucking Cock inside his girlfriend.
by SpaceBearX August 2, 2018
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"This is a big fucking deal" ~ Joe Biden to Obama, on passing healthcare reform
by Lildubchefin March 24, 2010
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When you want something obscenely/aggravatingly large to fuck off because of its annoying existence or presence.
person 1 : "can you get the salt please"
person 2 : "no Johns big fuck off ego is in the way"

or

person 1 : "Why isn't the traffic moving"
person 2 : "Because that big fuck off truck crashed in the middle of the road"
by jamzyyyy January 15, 2019
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A REALLY big spider with the seeming propensity to shred you tip to stern. When such spider walks, you can feel the fear through your feet, and the vibrations that it makes running after your ass. If you see one of these, you have one of 3 options.

-Run
-Get Eaten
-Start Praying
"Hey Jack, where did matt go?"
"I dont know for sure, but that really big fucking spider over there with a leg sticking out of its mouth sure looks suspicious..."
by Sebas S February 11, 2007
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