The condition where genitalia is in a perpetually happy state.
"Tom came down with a case of up-syndrome soon after meeting Caroline."

"We always thought Susie was a bit weird, but we didnt know for certain until her secret reared its ugly little head -- she was diagnosed with up-syndrome."

5:00 News Report:
"Rare condition found in man with up-syndrome... Are two penises better than one?"
by PetShelterPimp March 6, 2005
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When a person is sick and when they go to use the bathroom to take a dump, a sudden urge of vomiting arise and with no to wipe, flush, and pull your pants up, they get on their knees and vomit with their naked butt up in the air.
My mom caught me in the bathroom with butt-up syndrome. She asked me "Saba why do you have your pants down when you are vomiting" I replied, "Because I didn't have time to wipe and pull them up!"
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When someone won't stop talking oh my god shut the FUCK UP
"blah blah blah blah blah blah blah"
'Shut up! You have critical shut the fuck up syndrome right now!'
"Oh, sorry. blah blah blah blah blah"
by chazwolf_ November 15, 2020
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1. when you have just dumped or been dumped, and you are feeling majorly low, and all you wanna do is sit around and cry and eat chocolates and strangle the teddy bear he gave you...

2. if you've just been parted from something you majorly love, and you're really down about it.
"dude...i'm suffering from PBUS"

"damn it! i can't believe i'm not the play is over, i'm having theatre PBUS!"
by converse_kid February 19, 2004
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when ur so bummed about just bein dumped by the person you loved, that you start acting like a total retard
"hey evrybody listen to this" (bends over and farts)
by giz May 25, 2004
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A fictional disease attributed to bitchy girls as an attempt to explain why they are the way they are.

Commonly abbreviated as SUCS.
Bitchy girl:
"I'm going to act like hot shit even though I'm not very attractive, then I'm going to get drunk and be a complete cunt to everyone that isn't a hot guy."

Observers:
"Looks like she's got Stuck Up Cunt Syndrome."
by The Coolest Amber Ever January 8, 2008
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When somethings is up beat and catchy but has a verrrrry dark meaning; mostly when it comes to music.
Yea that song suffers from "Pumped Up Kicks" Syndrome as it sounds very groovy and joyus but the song is actually about murder and rape
by BattleSteam3821 February 14, 2021
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