A person with a disease that causes limbs and organs to detach from his/her body. Lepers are usually highly skilled in art and music, and some have a great talent for animation.

Lepers are often found in the forests of northern Canada and Poland. They live in small forest houses, rarely leaving their safe shelters.

Other effects of leprosy are back injuries, carpal tunnel syndrome, and tendinitis/epicondylitis.
Yikes, that leper over there is insane.
by Anonymous April 8, 2003
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Root: Limited-English-Proficiency-er One who does not speak enough English to be comprehensible, particularly on the telephone.
Before Sharon got Caller ID, she frequently had jagged and partial conversations with many a leper trying to get a hold of the immigrant who last inhabited her new home.
by Kate Thompson For Real August 16, 2008
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A formerly good looking person who recently has gotten a mullet.
Also, a social outcast.
Person 1: Have you seen Billy Carrabino's haircut?
Person 2: Yeah, he's turned into a leper cause of that mullet he got.
by CTdoglovrr January 21, 2012
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1.For the use of lesser words; the slang use for a "crankhead"

2. One who tries too hard in life to be cool, knowingly knowing that they aren't but somehow pretend they are.
Man that dude with the shades on in the club is a leper.
by Breezy F. Baby August 12, 2007
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Shane "skinbad" Comofort,
irish form of a leper
Guy 1: that guy's arm just fell off!!!
Guy 2: maybe its shane comfort?
Guy 1: oh yeah, never mind
by Anonymous September 25, 2003
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A killjoy that sucks all the fun out of life with their pretentious, politically correct bullshit and find every joke offensive. Usually a miserable dolt with zero creativity and sense of humor, they infect their hosts and surrounding and destroy any chance of a good time.
Wow! I didn’t know that Dave was such a Humor Leper, you can’t crack joke without getting a lecture from him, leave him home next time
by Lord evil May 23, 2013
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The designated smoker's areas outside of office buildings or in airports.
I hate walking by the leper colony in the morning...it stinks!
by Zenanarchy June 17, 2018
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