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fo' shizzle my nizzle 

Originated in medival England in the 17th century, this phrase has changed in meaning completely, from the orignal shorthand denotation of "Alas! An advasary has come upon us! To the catupults!" to the modern definition of "Please grease up my penis."
Old: Bartholomew, the dastardly barbains are attacking! Foe Shizle mine nizle!

New: Bitch step up! Fo shizzle my nizzle!
fo' shizzle my nizzle by Darky April 9, 2003
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fo' shizzle my nizzle 

THE REAL DEFINITION!!!

Snoop Dogg did NOT originate the colliquialism of adding the suffix' -izzle, -eezy, -iggedy and so forth to common everyday phrases. If you actually know your hip-hop history, this type of language originated from "Double Dutch Bus" by the Gap Band. Download it and listen. Frequent examples of such rhetoric are sprinkled across the track.

However, to the credit of Snoop Dee-Oh-Double-Gee, he took something retarded and made it sound FULLY SHICK M8!

"Dizzuble Dizzutch, the Dizzuble Dizzutch!"
fo' shizzle my nizzle by R. Soul October 24, 2003

fo shizzle mah nizzle 

"fo shizzle mah nizzle" is a bastardization of "fo sho mah nigga" which is a bastardization of "for sure my nigger" which is a bastardization of "i concur with you wholeheartidly my african american brother"
ghetto person 1- "dat gurl at dat bbq wuz wak son"
ghetto person 2- "fo shizzle mah nizzle!"
me- you're lame.

fo shizzle ma nizzle bizzo 

<guy> Your a fucking Bastard
<cop> *smack*
<guy> fo shizzle ma nizzle bizzo

fo' shizzle my nizzle 

A modernized and extended version of the infamous Shakespearean Hamlet line, "To be ... or not to be?"
"Fo' shizzle ... o' no' fo' shizzle? Dat be the quizzle, my south-central British nizzle."

Fo' shizzle ma nizzle

i agree with you wholeheartedly, my african american brother.
dude1: this guy r teh ghey

dude2: fo' shizzle ma nizzle

fo shizzle ma nizzle

for sure my --insert colloquial expletive beginning with "n"-- .

Just to clarify... The "izzles" and "izzos" were introduced to urban pop culture by Double Dutch Bus in 1981, however, Snoop took it to a new level. Snoop interpolated Double Dutch Bus (which was written by Bill Bloom and Frankie Smith) and originally performed by Frankie Smith (NOT the Gap Band).
Dizzouble Dizzutch... Double Dutch.
fo shizzle ma nizzle by ebloom November 8, 2004