When you see two hot chicks hanging out with a fatter, uglier woman you can pinpoint this woman as 'the DUFF'. DUFF stands for Designated Ugly Fat Friend. Hot chicks usually have a DUFF to make themselves look even better, when compared to their DUFF.
by SmartyTarty September 23, 2015
Get the DUFFmug. Duff: John dats a cool new haircut
John: Thanks you gay
2 days later...
Duff: John i got ur cool new haircut
John: Thanks you gay
2 days later...
Duff: John i got ur cool new haircut
by M15A April 11, 2008
Get the Duffmug. 
Designated Ugly Fat Friend
One who accompanies two other girls to make them look better. Usually, without their own knowledge.
One who accompanies two other girls to make them look better. Usually, without their own knowledge.
There were two pretty girls accompanied by an uglier, fatter girl. The other girl was a DUFF, only there to make the other girls look better.
by wolfles July 27, 2015
Get the DUFFmug. 
A fictional spokesman for the beer company:
"Duff".
He represents all that is malty
and alcholic.
Tends to do alot of thrusting
to the song "Oh yeah" by Yello.
"Duff".
He represents all that is malty
and alcholic.
Tends to do alot of thrusting
to the song "Oh yeah" by Yello.
The simpsons.
"Duff man is thrusting in the direction
of the problem!"
"Duff man can never die,
only the actors who play him!"
"Duff man is thrusting in the direction
of the problem!"
"Duff man can never die,
only the actors who play him!"
by Phoebe April 6, 2004
Get the duff manmug. The wingman who takes one for the team and talks to the Designated Ugly Fat Friend (DUFF). So the player has the opportunity to pick up the babe.
by Frankie B Govan October 21, 2015
Get the DUFF Manmug.